Besides, various Kcr regulators, including KAT2B, DPF2, HDAC2, HDAC3, HDAC8, KAT8, MLLT3, SIRT1, TAF1, and YEATS2, were correlated with T stage, lymph node metastasis, and histologic grade. This evidence concerns the gene HDAC8 and metastatic malignant neoplasm in the lymph nodes.