We found that CREBBP (p = 0.001), EP300 (p = 0.011), KAT2A (p < 0.001), HDAC1 (p < 0.001), HDAC2 (p < 0.001), HDAC3 (p < 0.001), HDAC8 (p < 0.001), TAF1 (p = 0.004), and YEATS2 (p < 0.001) were significantly upregulated in HNSCC samples compared to normal samples, while KAT2B (p < 0.001) and SIRT2 (p < 0.001) were remarkably downregulated in HNSCC samples (Figure 1(b)). This evidence concerns the gene SIRT2 and head and neck squamous cell carcinoma.