More specifically, the expressions of CREBBP, EP300, TAF1, KAT6A, YEATS2, and SIRT1 and KAT2A, KAT8, HDAC1, HDAC2, HDAC3, and HDAC8 were significantly correlated with each other in HNSCC (Figure 3(c)). This evidence concerns the gene HDAC8 and head and neck squamous cell carcinoma.