Induction of an osteoarthritis-like phenotype in the ATDC5 chondrocytes was confirmed by a significant upregulation of il6, mmp13, and colx10a1 (Figures 7A–C) and a decrease in col2a1 and acan (Figures 7D, E) expression following treatment with IL-1β. This evidence concerns the gene MMP13 and osteoarthritis.