PTH and periodontitis: Wolf et al. (2016) used human periodontal ligament (hPDL) cells, which can exhibit osteoblastic properties, to model inflammatory PDD (Wolf et al., 2016). hPDL cells from the third molar, isolated from healthy subjects aged 12–14 years with no signs of periodontitis, and enriched CD8+ T cells, isolated from matched individuals, were either cultured alone or in combination and exposed to PTH (1–34). WNT10B expression was observed only in the T cells when PTH was added.