Specifically in acute myeloid leukemia (AML), WNT10B signals through FZD4 and FZD5, while in T-cell acute lymphoblastic leukemia, WNT10B signals through FZD6 (Lazzaroni et al., 2016; Cassaro et al., 2021). This evidence concerns the gene FZD4 and acute myeloid leukemia.