The diterpene Jatrophone, derived from the plant Jatropha isabelli, interfered with the oncogenic WNT10B/β-catenin/HMGA2 signaling axis and inhibited proliferation in TNBC MSL-subtypes (MDA-MB-231 and MDA-MB-157), BSL-1 subtypes (HCC-38 and MDA-MB-468), and TNBC PDX-derived cells. The gene discussed is WNT10B; the disease is hepatocellular carcinoma.