Numerous studies have found that the main components of YLTB (berberine, catechin, quercetin, and so on) have beneficial therapeutic effects in decreasing the levels of serum T (47, 48), TC (49), LH (48, 49), the ratio of LH/FSH (50), alleviating IR (47, 51, 52), dyslipidemia (51, 53) and other PCOS-related diseases. This evidence concerns the gene PLOD1 and metabolic syndrome.