Results of ROC analysis showed that six out of the ten hub FRDEGs might be potential signature genes for IDD, including KEAP1, MAPK1, HSPA5, TXNRD1, JUN, and HIF1A. KEAP1, the Kelch like ECH associated protein 1, has been found to exert promoting functions on ferroptosis (40). Here, HIF1A is linked to intervertebral disk degenerative disorder.