Western blotting (Figures 7A,B) and IHC (Figures 7C,E) results showed that compared with the Cisplatin group, SHD treatment significantly reversed the dysregulation of the related proteins Bcl-2, caspase-3, caspase-8, caspase-9, and Bax in the two pathways of apoptosis and improved cisplatin-induced AKI apoptosis in mice. The gene discussed is CASP8; the disease is acute kidney injury.