Some evidence suggests that the TGF-β pathway may lead to cisplatin-induced nephrotoxicity, and ginsenoside Rb3 can have a protective effect on nephrotoxicity in the treatment of oral cancer with CPT through TGF-β pathway-mediated mitochondrial apoptosis (Wu et al. 2021b). The gene discussed is TGFB1; the disease is lip and oral cavity carcinoma.