Although their metabolisms in the brain is still under investigation, a recent study revealed the neuroprotective potential of salicin against cerebral ischemia-reperfusion through the activation of the PI3K/AKT pathway and its antioxidant efficacy (Kim et al., 2015; Tawfeek et al., 2019; Park et al., 2021). This evidence concerns the gene AKT1 and brain ischemia.