CD4 and rheumatoid arthritis: The Bu Shen Tong Luo formula could regulate CD3, CD4, and CD8 T cells to improve the joint score of CIA-rats (Su et al. 2010), and it could inhibit the differentiation and maturation of OCs and bone absorption, promote bone reconstruction, alleviate systemic inflammatory response and joint swelling to treat RA and PMOP through the Chemerin, NF-κB, OPG/RANK/RANKL pathways.