Li (2021) Bu Shen Qu Han Zhi Wang decoction suppressed OC activity through OPG/RANK/RANKL, reducing the expression of MMP-13, TNF-α, IL-1, IL-2, IL-17, and RANKL to cure RA Li et al. (2017); Ma, (2021); Wu et al.,(2018); Yan, (2012); (Figure 2); (Table 1). The gene discussed is TNFRSF11A; the disease is rheumatoid arthritis.