Although fewer studies have been conducted defining the relationship between meningeal lymphatic drainage and the development of AD-related pathology, recent studies modulating meningeal lymphatic and deep cervical lymphatic drainage demonstrate effects on both Aβ and tau pathology in rodent models of AD (Da Mesquita et al., 2018; Patel et al., 2019; Wang et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.