TP53 and non-small cell lung carcinoma: Figure 5(j) demonstrates that treatment with HO-3867 attenuated the upregulation of DMT1 in p53 KO cells. In addition, the upregulation of iron levels was also attenuated in p53 KO cells (Figure 5(k)). HO-5637-mediated cell death was also much less in p53 KO cells than in NSCLC cells with wild-type p53 (Figure 5(l)).