The higher the expression levels of ACSM2A, IDUA, MAT2B, and NR1H4, the better the prognosis of patients with BLCA, on the contrary, the higher the expression levels of the other nine genes, the worse the prognosis of patients (all P < 0.05, Fig. 4). The gene discussed is ACSM2A; the disease is bladder transitional cell carcinoma.