In the present study, we found that CD34+/CD38− MPN NSC display numerous 'therapeutic' targets, including CD33, CD44, CD47, CD97, CD99, CD117, CD123, CD133, CD184, and CD274 (PD‐L1) independent of the type of MPN or molecular driver lesion. This evidence concerns the gene PROM1 and myeloproliferative neoplasm.