Neuroimaging studies have shown topographical conformity and association between tau pathology from tau positron emission tomography (tau-PET) and longitudinal brain atrophy-based neurodegeneration from magnetic resonance imaging (MRI), in cognitively unimpaired individuals [7], prodromal AD and/or AD dementia [4, 8, 9], and clinical subtypes of AD [10, 11]. The gene discussed is MAPT; the disease is Alzheimer disease.