The prevalence of the identified tau-PET patterns differed slightly from previous reports: on the continuous scale (Fig. 1 A, B), a large proportion of the individuals exhibited intermediate values of typicality and low values of severity (lower variance in prodromal AD and cognitively normal may suggest less heterogeneity); on the discrete scale (Fig. 4), minimal tau was the most prevalent pattern (37%) and the cortical predominant pattern (18%) was more prevalent than the limbic predominant pattern (12%). Here, MAPT is linked to Alzheimer disease.