MAPT and Alzheimer disease: To this end, our study aims to provide two complementary perspectives on this issue (see Supplementary Figure 1 for study design): (a) Biological perspective: we investigated the association between different tau-PET patterns and longitudinal atrophy in the AD continuum (cognitively normal, prodromal AD, AD dementia cases with Aβ pathology); and (b) Methodological perspective: we characterized tau-PET patterns on a continuous scale inspired by the recent conceptual framework [17], compared to and extending beyond the conventional characterization of discrete categorization [14–16, 18].