CRLF3 also plays a role in the maturation of proplatelets, with CRLF3 deficiency contributing to thrombocytopenia due to inefficient thrombopoiesis, with preplatelets, which are larger than the mature platelets, circulating for longer and being destroyed in the spleen before managing to mature into platelets [38]. This evidence concerns the gene CRLF3 and Thrombocytopenia.