Two PUFA were associated with the non-APOE AD PRS (PT = 0.1; DPA: ß =  − 0.077, 95% CI = [0.13, − 0.029], p = 0.0018; linolenate: ß =  − 0.054, 95%CI = [− 0.10, − 0.0056], p = 0.029, pFDR > 0.05); these associations weakened with the APOE region additionally included (PT = 0.1; DPA: ß =  − 0.058, 95% CI = [− 0.11, − 0.0097], p = 0.019, linolenate: ß =  − 0.040, 95% CI = [− 0.088, 0.0088], p = 0.11). This evidence concerns the gene APOE and Alzheimer disease.