Here, we found that Gsk3b, Notch2, Pik3cb, Myc, Cdkn1a, and Smad3 were increased in human lung cancer tissue and Cd‐transformed cells, while Pik3cb, Myc, Cdkn1a, and Smad3 were negatively correlated with circCIMT. This evidence concerns the gene PIK3CB and lung cancer.