Here, we found that Gsk3b, Notch2, Pik3cb, Myc, Cdkn1a, and Smad3 were increased in human lung cancer tissue and Cd‐transformed cells, while Pik3cb, Myc, Cdkn1a, and Smad3 were negatively correlated with circCIMT. The gene discussed is SMAD3; the disease is lung cancer.