Misdiagnosis of EBV infection as diffuse large B-cell lymphoma (DLBCL) has also been reported, as the CD20 + /CD30 + /MUM1 + /EBER-ISH + immunoblasts of EBV infection may be present in sheets with associated necrosis and marked distortion of node architecture [9]. The gene discussed is TNFRSF8; the disease is diffuse large B-cell lymphoma.