Melanoma treatment is based on these multi-factors, starting from total prevention by avoidance from exposure to UV radiation of the sun, and with the progress of the disease targeted biological treatment, such as, BRAF inhibitors, MEK inhibitors, immune checkpoint strategies like CTLA4 antibodies [11] and immune checkpoint strategies like PD-1 antibodies [10, 27]. The gene discussed is BRAF; the disease is melanoma.