TP53 and cancer: Further functional GSEA revealed that the altered genes (including mRNA and lncRNA) were significantly enriched in autophagy, cancer, and immune-related pathways, for example, pathways in cancer (p = 0.032), mTOR signaling pathway (p = 0.008), p53 signaling pathway (p = 0.045), NOD-like receptor signaling pathway (p = 0.006), Toll-like receptor signaling pathway (p = 0.021), regulation of actin cytoskeleton (p = 0.01), chemokine signaling pathway (p = 0.019) in patients with high risk of TSCC (Fig. 7).