CDK1 and cancer: CDK1-mediated mitotic phosphorylation of PBK was reported to be involved in cytokinesis and tumorigenesis [56], while one study indicated that CDK1 was identified to be a MYC synthetic-lethal gene and the inhibition of CDK1 selectively induces apoptosis in MYC-dependent cancer cell lines by upregulating the pro-apoptotic molecule BIM [57].