Furthermore, we examined the clinical relevance of pVHL by analyzing Kaplan-Meier database and found that individuals with high VHL expression in TNBC and other cancers harboring wild-type VHL such as pancreatic ductal adenocarcinoma and rectum adenocarcinoma, showed higher recurrence-free survival, which is consistent with previous studies [23, 24] (Supplementary Fig. 1J–L). This evidence concerns the gene VHL and rectum adenocarcinoma.