More importantly, the cooperative regulation of pVHL stabilization by PIN1 and CDK1 might be a common regulatory mechanism in caners harboring wild-type VHL, since PIN1/CDK1-pVHL signaling axis exists not only in TNBC, but also in other cancer types harboring wild-type VHL including pancreatic cancer, colorectal cancer, ovarian cancer and other subtypes of human breast cancers. This evidence concerns the gene PIN1 and familial pancreatic carcinoma.