In addition to HIFα, VHL also inhibits NF-κB signaling by mediating K63-ubiquitination of IKKβ [29], and our previous study have verified that elevated VHL could inactivate β-catenin pathway, and impair the capacities of proliferation and invasion in oral squamous cell carcinoma [30]. Here, IKBKB is linked to oral cavity squamous cell carcinoma.