Besides, the expressions of N-cadherin, Vimentin, Snail and Cyclin D1 were restored by si-VHL transfection in MALAT1-silenced HNSCC cells (Fig. 5B and Supplementary Fig. 11); while, VHL knockdown led to a decrease of E-cadherin in si-MALAT1-transfected HNSCC cells (Fig. 5B, C and Supplementary Fig. 12). Here, CDH2 is linked to head and neck squamous cell carcinoma.