The ferroptosis signature was positively associated with tumor immunogenicity, and ferroptosis inducers could inhibit tumor growth and sensitize the tumors to IFNγ and immune checkpoint blockade.4 Moreover, ferroptosis in tumor-infiltrating CD8+ T cells could impair anti-tumor immunity and promote tumor progression.5 Thus, ferroptosis induction for cancer therapy must consider the complex nature of ferroptosis in the tumor microenvironment. The gene discussed is CD8A; the disease is neoplasm.