Ren et al. (2022) reported that ACE2 polymorphisms could impact susceptibility to infection by SARS-CoV-2, SARS-CoV, and HCoV-NL63. For example, ACE2 variants D355N and G352V restrict the S protein-ACE2 interaction and limit infection, where HCoV-NL63 S protein binds to ACE2 less efficiently (Ren et al., 2022). The gene discussed is PROS1; the disease is infection.