Promoter analyses has revealed that the human P-gp gene promoter harbors NF-κB responsive elements, which bind with NF-κB to promote P-gp gene expression (11, 12) but that inhibition of the NF-κB signaling pathway decreases P-gp expression, which increases apoptotic cell death in response to daunomycin treatment in human colorectal adenocarcinoma cells (12). The gene discussed is PGP; the disease is colorectal adenocarcinoma.