In this respect, some studies have also found no relationship between these NLRP3 polymorphisms and inflammatory conditions,33, 34although Isaza-Guzmán et al reported an association between NLRP3 rs4612666 and chronic periodontitis in the Colombian population35; however, this study was lacking the ethnicity of chronic periodontitis patients and healthy controls, which may have explained some confounding influence of population stratification that could not be detected. This evidence concerns the gene NLRP3 and periodontitis.