Polymorphism of NLRP3 is one of the most studied SNPs of all the inflammasomes in inflammatory and autoimmune diseases; NLRP3 has been implicated as having a key role in the pathogenesis of several diseases in the general population, including obesity, DM, rheumatoid arthritis,28, 29all of which are clinical diseases known for their association with periodontitis.14, 23, 30, 31. This evidence concerns the gene NLRP3 and diabetes mellitus.