This, in turn, increases the transcriptional activity of theNLRP3gene, and overexpression of cytokine and caspase, which leads to an exacerbated inflammation pathway in the periodontal tissue during the pathogenesis of the periodontal disease and leads to bone loss.14, 27, 32This is corroborated by the significant association between NLRP3 polymorphism and rising attachment loss. This evidence concerns the gene NLRP3 and periodontal disorder.