Furthermore, various studies have discovered that genotypic polymorphisms are connected with phenotypic variety, such as periodontitis severity and onset.9, 10, 11, 12, 13One such polymorphism is the NLRP3, there are a few studies that have looked at the NLRP3 polymorphism as it relates to periodontitis.14Hence, the purpose of this study was to explore the association of polymorphisms in theNLRP3gene with periodontitis in the Arabs populations of Iraq. This evidence concerns the gene NLRP3 and periodontitis.