IL18 and periodontitis: Pathogenic microorganisms activate the host immune system.3, 4Particularly, inflammasomes are intracellular pattern recognition receptors that become active when several signals are recognized as pathogen-associated molecular patterns (PAMPs).5The most intricate of them all, the nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes react to PAMP.6Increased secretion of mature interleukin (IL)-1β, caspase-1, and IL-18, which have a critical role in the host innate immune reactions during periodontitis, is brought on by the NLRP3 inflammasomes' formation and activation.6, 7