According to Lubov et al, several miRNAs have a significant role in the regulation and expression of genes in HNSCC, either as oncogenes or tumor suppressors.28miR-21 is one of the first oncomiRs discovered to be increased in a number of malignancies, including gliomas, breast cancer, and colorectal cancer.29miR-21 is overexpressed in HNSCC and targets the actin-binding protein tropomyosin 1, which is essential for maintaining the cell skeleton. This evidence concerns the gene TPM1 and breast cancer.