Here, we show that an increase in specific inflammatory and acute phase proteins over time (e.g., SAA1;SAA2, CRP, ITIH3, LRG1, SERPINA1, and LBP) is associated with the risk of death from COVID-19, while an increase of kallikrein (KLKB1), kallistatin (SERPINA4), thrombin (F2), apolipoprotein C3 (APOC3), GPLD1, and the protease inhibitor A2M, is associated with survival. Here, APOC3 is linked to COVID-19.