However, in 57 ESCC patients without surgery, we found that EGFR and PD-L1 co-expression were statistically correlated with a lower ORR (p = 0.029), OS (p = 0.018), and PFS (p = 0.045) than EGFR (−)/PD-L1 (−), EGFR (+)/PD-L1 (−) and EGFR (−)/PD-L1 (+) subgroups. This evidence concerns the gene EGFR and esophageal squamous cell carcinoma.