One stage II (pT4N0) MMR-proficient cancer (with the Gly17Glu mutation of the RHOA gene) occurred in the nonampullary duodenum of a 50-year-old man, while the other one, a stage III (pT3N1) MMR-proficient SBA (with the Tyr42Cys mutation), was found in the ileum of a 52-year-old female patient. This evidence concerns the gene RHOA and cancer.