The association of IDH1 molecular alterations with IBD-related neoplasms appeared to be confirmed in the small intestine by both Aparicio et al,8 who identified IDH1 mutations in 1% of their sporadic SBAs in contrast to 28.6% of Crohn disease–related SBAs, and by Liao et al,29 who observed IDH1 mutation exclusively in Crohn disease–related SBAs (18%). This evidence concerns the gene IDH1 and Crohn disease.