KRAS and cancer: This result is intriguing if we consider a recent study reporting a strong relationship between a history of IBD and the occurrence of KRAS-amplified metastatic CRCs.46KRAS amplifications have been reported in about 19% of SBAs by Hänninen et al.7 Several studies demonstrated in different cancer entities that amplifications occurred mutually exclusively with mutations in KRAS and that amplifications were usually associated with poor prognosis in most cases.47-49