AKT1 and inflammatory bowel disease: On the other hand, no RHOA mutation was identified in a whole-exome sequencing analysis of 32 IBD-associated colorectal cancers, as opposed to our SB-PCCs related to Crohn disease, which showed RHOA mutations in 17% of cases.57 Nevertheless, in the study by Robles et al,57 genes involved in the Rho and Rac GTPase network were reported to be recurrently mutated in 30% of cases.