Likewise, PIK3CA, which has been identified by various authors as one of the most frequently mutated genes in SBAs (8%-33%),6-8,29 with a trend for more frequent PIK3CA alterations in Crohn disease–associated SBAs (up to 43%),8 was never found to be mutated in SB-PCCs of our series. Here, PIK3CA is linked to Crohn disease.