The latter histologic feature is intriguing because (1) RHOA mutations have also been described in appendiceal GCAs,35 and (2) RHOA-mutated diffuse-type gastric cancers have been reported to be characterized by a superficial SRC or tubular differentiation and a deep invasive PCC-NOS, more desmoplastic, component.13,38 Whether such RHOA-mutated small bowel cancers with minor, low-grade GCA-like components are better classified as “extra-appendiceal GCAs with prominent PCC component” rather than as SB-PCCs requires further evidence. The gene discussed is RHOA; the disease is temporal arteritis.