Recent molecular studies identified APC, a Wnt-pathway gene whose mutations represent one of the early events in the colorectal carcinogenic process, as one of the most commonly mutated genes in SBAs (13%-27%),2,6-8 although its alterations occurred more rarely (0%-6%) in Crohn disease–associated SBAs.6,8,29 In keeping with these observations, APC pathogenic mutation was identified only in one (7%) case of our series, which was enriched with Crohn disease–related cases. The gene discussed is APC; the disease is Crohn disease.