Meanwhile, the allograft reject and graft-versus-host disease gene sets were down-regulated (Fig. 3G), while a group gene sets related to acquired immunity (regulation of T cell differentiation, alpha-beta T cell activation, and regulation of alpha-beta T cell activation; normal myeloid leukocyte morphology and abnormality of neutrophils; and immunoglobulin receptor binding and positive regulation of B cell activation) was up-regulated, accompanied by the up-regulation of immunodeficiency (Fig. 3H), implying an immunosuppressive regulatory role of the endothelium induced by IDX. This evidence concerns the gene MPIG6B and immune system disorder.