For our experiments, we selected a tauopathy model in which human pro-aggregating tau fragment, F3ΔK280, and the full-length mutant tau protein (V337M) were coexpressed in all neurons, and the GABAergic (γ-aminobutyric acid–releasing) motor neurons are labeled by GFP (Prab-3::F3ΔK280; Paex-3::h4R1NTauV337M; Punc-25::GFP) (Fig. 4, A and B) (9). The gene discussed is IGDCC3; the disease is tauopathy.