SQSTM1 and myelodysplastic syndrome: In the Lin−CD34+CD38−CD123−CD45Ra− population, which is enriched for HSCs in both healthy BM and pre-MDS stem cells (35), we observed a significant increase in LC3 and P62 in pre-MDS stem cells, suggesting that these cells have perturbed autophagy and autophagosomal cargo accumulation (Fig. 7, A to C).