Current studies have illustrated that RPL23 could modulate p53‐correlated cell apoptosis and cell cycle arrest through MDM2‐p53 feedback loop modulation in in vitro experiments in carcinomas of the stomach,69, 70 colon,71 and lung,72 suggesting the involvement of the RPL23‐MDM2‐p53 pathway checkpoint in malignancies. Here, MDM2 is linked to gastric carcinoma.