IL-23, a cytokine involved in inflammation and autoimmunity, is a heterodimer composed of two subunits, p19 and p40, which can bind to the IL-23 receptor on T-helper 17 (Th17) cells and drive the expansion of Th17 cells to produce more pro-inflammatory factors to trigger joint and synovial inflammation. This evidence concerns the gene IL37 and Autoimmunity.