BCL2 and diffuse large B-cell lymphoma: For instance, old DLBCL patients are usually associated with poor prognostic factors such as late Ann Arbor stage, high-level lactate dehydrogenase (LDH) in serum, multiple extranodal involvements, non-germinal center B‐cell (non-GCB) phenotype, MYC/BCL2 double expression, and Epstein-Barr virus (EBV) infection [3, 4].