TGFB1 and Hepatic fibrosis: TGF-β1 also induces fibrosis by supporting the differentiation of inactive fibroblasts into matrix-secreting myofibroblasts (Vaughan et al. 2000; Lijnen et al. 2003) and increasing the synthesis of collagen (Epstein et al. 1994; Koh et al. 2015) in the ECM, exacerbating hepatic fibrosis (George et al. 2019).