Due to the fact that P-Tex cells were benefit to the prognosis of HPV-positive HNSCC patients, we speculated that the inhibition of CDK4 inhibitors on P-Tex cells might be one of the reasons why promising treatment outcomes of CDK4 inhibitors were not observed in HPV-positive HNSCC patients (Adkins et al., 2019; Oppelt et al., 2021; van Caloen and Machiels, 2019). This evidence concerns the gene CDK4 and head and neck squamous cell carcinoma.