Given the correlations with several features of genome instability in the PCa clinical data, we sought to identify genes impacted by hSSB1 depletion and at 24 h following the induction of DNA damage by 6 Gy of IR, to examine the transcriptional impact following the response to DNA damage and cell cycle checkpoint recovery where hSSB1 is demonstrated to function. The gene discussed is NABP2; the disease is posterior cortical atrophy.