To understand the mechanisms by which HIP1R modulates the malignancy of PAAD cells, we performed GSEA (Gene Set Enrichment Analysis) (http://www.gsea‐msigdb.org/gsea/index.jsp), which indicates that high HIP1R expression is negatively associated with PI3K/Akt pathway (Figure 7A). This evidence concerns the gene HIP1R and pancreatic adenocarcinoma.