HIP1R and pancreatic adenocarcinoma: The methylation levels of HIP1R promoter in PAAD cell lines (PANC‐1: 81%, SW1990: 73%, BxPC‐3: 71%) and PAAD patient tissues (76% and 65%) were much higher than that of normal pancreatic duct epithelial cell line HPDE‐6 (39%) (Figure 3C).