These findings add novel insights into the functions of HIP1R in PAAD, which are of valuable clinical significance: HIP1R could serve as a potential prognostic marker in PAAD, and targeting DNA methylation and miR‐92a‐3p could be used as a strategy to restore the tumour suppressor function of HIP1R to curb the progression of PAAD. This evidence concerns the gene HIP1R and neoplasm.