In vitro experiments on the treatment of oral squamous cell carcinoma cell lines with MCT1/MCT4 inhibitors combined with radiotherapy showed that the proliferation, migration, and cladogenesis of the cancer cells were significantly reduced; thus, these findings demonstrate that MCT1/MCT4 inhibitors and radiotherapy have a synergistic anti-tumor effect (Brandstetter et al., 2021). This evidence concerns the gene SLC16A3 and cancer.