In addition, their study showed that the LDHA inhibitor oxalate oxamate, when combined with the glycolysis inhibitor 2-deoxy-d-glucose, effectively enhanced the antitumor effects of temozolomide, improved the radiosensitivity of glioblastoma, and triggered apoptosis and differentiation of cancer stem cells (Koukourakis et al., 2017). This evidence concerns the gene LDHA and cancer.