LDHA and glioblastoma: In addition, their study showed that the LDHA inhibitor oxalate oxamate, when combined with the glycolysis inhibitor 2-deoxy-d-glucose, effectively enhanced the antitumor effects of temozolomide, improved the radiosensitivity of glioblastoma, and triggered apoptosis and differentiation of cancer stem cells (Koukourakis et al., 2017).