Most clear cell renal cell carcinomas (ccRCC) exhibit inactivation of the von Hippel–Lindau gene (VHL), leading to stabilization of hypoxia‐inducible factors 1 and 2 alpha (HI1/2α) and consequent overexpression of VEGF [9, 10]. The gene discussed is VEGFA; the disease is nonpapillary renal cell carcinoma.