SERPINE1 and neoplasm: These genes, including CXCL1, SDC1, SDC2, EDN1, and KIT, are involved in invasion, migration, angiogenesis, inflammation, metastasis and tumour progression and have been identified as therapeutic targets in several types of cancer: CXCL1 [49, 50], SERPINE1 (PAI-1) [51, 52], SDC1 [53, 54], KIT [55], EDN1 [56], SDC2 [57], TGFB2 [58, 59], ITGA6 [60], VEGFC [61], and CD58 [62].