Liver insulin resistance is confirmed by the impaired phosphorylation of Akt at both residues, Thr308 (Fig. 3F,G) and Ser473 (Fig. 3F,H), as well as the impaired phosphorylation of ACLY at Ser455 (Fig. 3F,I), a downstream target of Akt. The gene discussed is ACLY; the disease is Insulin resistance.