Corroborating these results, C/EBP Homologous Protein (CHOP), a downstream target of the different branches of UPR pathway, was also upregulated upon both treatments, HFHS and HFHSw (Fig. 4A,E), confirming that the continuous low-frequency HFHS consumption promotes and sustains several markers of Western diet-induced insulin resistance in mice. This evidence concerns the gene DDIT3 and Insulin resistance.