After including the normal tissue of the GTEx dataset as controls, the expression of REST mRNA was significantly upregulated in 9 cancer types, including DLBC (tumor 47 and normal 337), ESCA (tumor 182 and normal 286), GBM (tumor 163 and normal 207), LAML (tumor 173 and normal 70), LGG (tumor 518 and normal 207), PAAD (tumor 179 and normal 171), STAD (tumor 408 and normal 211), TGCT (tumor 137 and normal 165) and THYM (tumor 118 and normal 339) (Fig. 1B, P < 0.05). The gene discussed is REST; the disease is neoplasm.