Compared with their expression in WT mice, overexpression of Klf7 significantly downregulated PFKL expression and upregulated ACADL expression in 3-week TG mice after birth, and ACADL expression was reduced at 12-week, suggesting that the ability of the TG mice to carry out glycolysis and fatty acid metabolism was reduced at 12 weeks, and the mice exhibited a severe HF phenotype at this stage (Fig. 5b, c and Supplementary Fig. 9l). The gene discussed is PFKL; the disease is hydrops fetalis.