To clarify whether KLF7 is involved in the process of cardiac hypertrophy, we used AngII to treat human cardiomyocyte cell line AC16 to induce cardiomyocyte hypertrophy model, and the results showed that the expression of Klf7 decreased in hypertrophic cardiomyocytes (Fig. 1a, b). This evidence concerns the gene KLF7 and cardiac hypertrophy.