As another example, we identified the involvement of the NECTIN-TIGIT signaling pathway during the interaction between the TAM (source) and TRM CD8+ T cells (target), which is supported by a previous report that NECTIN (CD155) expressed on TAM could be immunosuppressive when interacting with surface receptors, TIGIT, on CD8+ T cells in the lung cancer TME29,30. This evidence concerns the gene PVR and lung carcinoma.