TGFB1 and neoplasm: Similarly, the KEGG enrichment analysis identified certain signaling pathways associated with tumorigenesis, tumor development, and some classical pathways in tumors, including the ECM-receptor interaction, PI3K-AKT signaling pathway, cGMP-PKG signaling pathway, TGF-β signaling pathway, Hippo signaling pathway, and Wnt signaling pathway (Figure 4B).