Finally, a body of literature has established that RTEs and ERVs become inappropriately expressed not only in TDP-43 related disorders ALS and FTD12–21,56,57, but also in some disorders with Tau pathology (AD and Progressive supranuclear palsy)58,59 and in Aicardi-Goutieres syndrome60,61. Here, MAPT is linked to amyotrophic lateral sclerosis.