PINK1 and cardiomyopathy: These studies showed that high glucose exposure or cardiomyopathy resulted in the membrane potential of mitochondria was decreased in these pathogenic conditions where melatonin upregulated PINK1 more efficiently whereas glucocorticoid exposure did not trigger membrane potential change in neuronal cells, where melatonin action on PINK1-mediated mitophagy could not effectively restore mitochondrial function.